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. 1996 Aug 15;56(16):3711-5.

A new process of cancer prevention mediated through inhibition of tumor necrosis factor alpha expression

M Suganuma  1 , S Okabe, E Sueoka, N Iida, A Komori, S J Kim, H Fujiki
Affiliations
  • PMID: 8706012

A new process of cancer prevention mediated through inhibition of tumor necrosis factor alpha expression

M Suganuma et al. Cancer Res. .

Abstract

Mechanisms of cancer prevention were studied using structurally different cancer-preventive agents, sarcophytol A, canventol, (-)-epigallo-catechin gallate, and tamoxifen, based on our evidence that tumor necrosis factor alpha (TNF-alpha) acts as an endogenous tumor promoter relevant to human carcinogenesis. Pretreatment with the four preventive agents commonly inhibited TNF-alpha mRNA expression and TNF-alpha release in BALB/3T3 cells induced by a tumor promoter, okadaic acid, whereas the expression of early response genes (c-jun, junB, c-fos, and fosB) was enhanced. These results strongly suggest that inhibition of TNF-alpha mRNA expression and its release is a new process of cancer prevention.

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