Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Jun;90(6):1019-21.
doi: 10.1016/s0022-3476(77)80587-8.

Methotrexate hepatotoxicity in children with leukemia

S McIntosh, D L Davidson, R T O'Brien, H A Pearson

Methotrexate hepatotoxicity in children with leukemia

S McIntosh et al. J Pediatr. 1977 Jun.

Abstract

Percutaneous liver biopsy was performed on seven children with acute lymphocytic leukemia who had received maintanance chemotherapy with high-dose intravenous methotrexate for 1 1/2 to 2 1/2 years. Portal fibrosis was found in four of the seven children and in an additional patient treated with oral methotrexate. Serial tests of liver function and 99mtechnetium-sulfur-colloid scans did not accurately identify children with hepatic fibrosis. Clinical evidence of liver disease was not seen.

PubMed Disclaimer

Publication types

MeSH terms