Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977:297 Suppl 1:S89-93.
doi: 10.1007/BF00587790.

Influence of prostaglandins on connective tissue cell growth and function

H D Peters, B A Peskar, P S Schönhöfer

Influence of prostaglandins on connective tissue cell growth and function

H D Peters et al. Naunyn Schmiedebergs Arch Pharmacol. 1977.

Abstract

Prostaglandins (PGs) are synthesized by cultured fibroblasts. PGs regulate specific cellular functions by influencing cyclic nucleotide levels. PGE1 increases cAMP levels, thus enhancing glycosaminoglycan (GAG) synthesis and reducing proliferation. Exogenous cyclic nucleotides, on the other hand, affect PG formation. Glucocorticoids (GCs) decrease cAMP content, GAG synthesis and PG formation in fibroblasts, the latter effect occurring only after prolonged incubations. The decrease in endogenous PG levels causes a sensitization of the cells to exogenous PGE1, thus counteracting the initial inhibitory effect of GCs on cAMP content and GAG synthesis. Cell proliferation shows an inverse relationship to PG-induced changes in cAMP levels.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Biochem Biophys Res Commun. 1972 May 26;47(4):888-96 - PubMed
    1. J Biol Chem. 1976 Feb 10;251(3):776-80 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Jul;72(7):2724-8 - PubMed
    1. Exp Cell Res. 1974 Mar 15;84(1):40-6 - PubMed
    1. Nat New Biol. 1973 May 9;243(123):50-1 - PubMed