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. 1996 Jul 5;39(14):2705-9.
doi: 10.1021/jm960142x.

Preparation of phenolic paclitaxel metabolites

H Park  1 , M Hepperle, T C Boge, R H Himes, G I Georg
Affiliations

Preparation of phenolic paclitaxel metabolites

H Park et al. J Med Chem. .

Abstract

The synthesis and biological evaluation of the two known phenolic metabolites of paclitaxel are described. The C3'-phenolic metabolite 2 of paclitaxel was prepared from 7-(triethylsilyl)-baccatin III (8) and enantioenriched N-benzoyl-2-azetidinone 7. The C2-phenolic metabolite 3 was synthesized from paclitaxel (1a) via selective C2 debenzoylation and reacylation.

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