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. 1996 Sep;156(3):943-6.

Increased urinary levels of Tamm-Horsfall glycoprotein suggest a systemic etiology of interstitial cystitis

J J Bade  1 , J Marrink, A Karrenbeld, L van der Weele, H J Mensink
Affiliations
  • PMID: 8709369

Increased urinary levels of Tamm-Horsfall glycoprotein suggest a systemic etiology of interstitial cystitis

J J Bade et al. J Urol. 1996 Sep.

Abstract

Purpose: We investigated the role of Tamm-Horsfall protein in interstitial cystitis.

Materials and methods: Urinary Tamm-Horsfall protein excretion was analyzed in interstitial cystitis patients and controls, and bladder biopsy specimens were stained immunohistochemically for Tamm-Horsfall protein.

Results: Urinary Tamm-Horsfall protein levels in 28 women with interstitial cystitis were statistically significantly greater than those in 25 female controls. No positive staining for Tamm-Horsfall protein was demonstrated in the bladder tissue from 10 interstitial cystitis cases.

Conclusions: The results support the notion that interstitial cystitis may have a systemic etiology. In addition, this assay might have clinical value in the diagnosis of interstitial cystitis.

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