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. 1977 Apr;16(4):687-94.

Suppression of the primary immune response by chemical sympathectomy

K Kasahara, S Tanaka, T Ito, Y Hamashima
  • PMID: 870955

Suppression of the primary immune response by chemical sympathectomy

K Kasahara et al. Res Commun Chem Pathol Pharmacol. 1977 Apr.

Abstract

The effects of general sympathectomy with 6-hydroxydopamine (6-OHDA) on antibody production to sheep red cells (SRBC) were studied in mice. Intraperitoneal administration of 6-OHDA in a dose of 1 to 300mg/kg resulted in a significant decrease in hemagglutinin titer and number of direct plaque-forming cells which were observed only in the early period of the primary immune response. Following treatment with 6-OHDA 10mg/kg i.p., the noradrenaline content in murine spleen was significantly reduced from 63 to 42% of control value between 2 and 10 days after injection indicating that chemical sympathectomy suppresses the primary immune response.

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