doi: 10.1126/science.870966.
Mouse chromosome translocations: visualization and analysis by electron microscopy of the synaptonemal complex
- PMID: 870966
- DOI: 10.1126/science.870966
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Mouse chromosome translocations: visualization and analysis by electron microscopy of the synaptonemal complex
Science.
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Abstract
Pachytene chromosomes of mice heterozygous for known translocations are clearly depicted by configurations of the synaptonemal complexes in spread (whole mount) preparations. In one autosomal and two X-autosome translocations analyzed, breakpoints are identifiable; localization by measurement agrees with mitotic data and shows the translocations to be reciprocal. Synapsis with the Y is inhibited in one translocation in which the breakpoint is the pairing region of the X.
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