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. 1977 May 20;196(4292):892-4.
doi: 10.1126/science.870966.

Mouse chromosome translocations: visualization and analysis by electron microscopy of the synaptonemal complex

M J Moses, L B Russel, N L Cacheiro

Mouse chromosome translocations: visualization and analysis by electron microscopy of the synaptonemal complex

M J Moses et al. Science. .

Abstract

Pachytene chromosomes of mice heterozygous for known translocations are clearly depicted by configurations of the synaptonemal complexes in spread (whole mount) preparations. In one autosomal and two X-autosome translocations analyzed, breakpoints are identifiable; localization by measurement agrees with mitotic data and shows the translocations to be reciprocal. Synapsis with the Y is inhibited in one translocation in which the breakpoint is the pairing region of the X.

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