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Review
. 1996 Aug 10;348(9024):379-83.
doi: 10.1016/s0140-6736(96)01034-3.

Gastrointestinal manifestations of HIV infection

D Sharpstone  1 , B Gazzard
Affiliations
Review

Gastrointestinal manifestations of HIV infection

D Sharpstone et al. Lancet. .

Abstract

The harrowing picture of emaciated terminally ill AIDS patients is a reminder of our lack of understanding of immunological mechanisms that normally control opportunistic infections. Many gastrointestinal pathogens in patients with AIDS are resistant to treatment and lead inexorably to weight loss and death. Although knowledge of the pathogenesis and clinical significance of weight loss has improved considerably, this has not yet led to a sustained effort to improve nutritional status during early stages of disease.

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Figures

Figure
Figure
Electronmicrograph of duodenal mucosa enterocytes from patient with AIDS-related diarrhoea showing a plasmodium of Enterocytozoon bieneusi (arrowed) and an oocyst of Cryptosporidium parvum (top right) Identification bar= 1 micron. Courtesy of G Tovey and Dr D Ellis, London School of Hygiene and Tropical Medicine
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Comment in

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