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Review
. 1996:47:11-20.
doi: 10.1146/annurev.med.47.1.11.

Gene transfer to hematopoietic stem cells: implications for gene therapy of human disease

C E Dunbar  1
Affiliations
Review

Gene transfer to hematopoietic stem cells: implications for gene therapy of human disease

C E Dunbar. Annu Rev Med. 1996.

Abstract

Transfer of new genetic material to hematopoietic stem cells and expression of the gene product in daughter cells of various lineages is an exciting approach to the treatment of congenital and acquired human diseases. This review summarizes the current status of retroviral and adeno-associated viral vectors for gene transfer to human hematopoietic cells, including extensive preclinical data as well as preliminary results from ongoing clinical trials.

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