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. 1996 Feb;46(2):169-71.

Free radical scavenging activity of curcuminoids

N Sreejayan  1 , M N Rao
Affiliations
  • PMID: 8720307

Free radical scavenging activity of curcuminoids

N Sreejayan et al. Arzneimittelforschung. 1996 Feb.

Abstract

Three natural curcuminoids (curcumin (CAS 458-37-7), demethoxycurcumin, bisdemethoxycurcumin) and acetylcurcumin were compared for their ability to scavenge superoxide radicals and to interact with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) stable free radicals. The results showed that curcumin is the most potent scavenger of superoxide radicals followed by demethoxycurcumin and bisdemethoxycurcumin. Acetylcurcumin was inactive. Interaction with DPPH showed a similar activity profile. The study indicates that the phenolic group is essential for the free radical scavenging activity and presence of methoxy group further increases the activity.

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