Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Aug;37(8 Pt 1):2538-43.

Identification of aldophosphamide as a metabolite of cyclophosphamide in vitro and in vivo in humans

C Fenselau, M N Kan, S S Rao, A Myles, O M Friedman, M Colvin
  • PMID: 872080

Identification of aldophosphamide as a metabolite of cyclophosphamide in vitro and in vivo in humans

C Fenselau et al. Cancer Res. 1977 Aug.

Abstract

Aldophosphamide (NSC 254), a putative key metabolite of cyclophosphamide, has now been isolated as a cyanohydrin derivative from an incubation mixture of cyclophosphamide with mouse liver microsomes in vitro and from the plasma of a cyclophosphamide-treated patient. The cyanohydrin has been shown to be identical with an authenic synthetic sample by mass spectrometry and combined gas chromatography-mass spectrometry.

PubMed Disclaimer

Publication types