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. 1996 May;40(5):1257-9.
doi: 10.1128/AAC.40.5.1257.

Directly repeated insertion of 9-nucleotide sequence detected in penicillin-binding protein 2B gene of penicillin-resistant Streptococcus pneumoniae

A Yamane  1 , H Nakano, Y Asahi, K Ubukata, M Konno
Affiliations

Directly repeated insertion of 9-nucleotide sequence detected in penicillin-binding protein 2B gene of penicillin-resistant Streptococcus pneumoniae

A Yamane et al. Antimicrob Agents Chemother. 1996 May.

Abstract

We investigated the molecular mechanism of 50 penicillin-resistant Streptococcus pneumoniae strains (penicillin: MIC, > or = 0.125 microgram/ml) having neither class A nor class B mutations in the penicillin-binding protein 2B gene (pbp2b). An analysis of the nucleotide sequences of the pbp2b genes from seven strains revealed an unique direct repeat of 9 nucleotides (TGGTATACT) between active-site serine (residue 385) and Ser-X-Asn (residues 442 to 444) motifs. The same insertion was detected in 13 strains.

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References

    1. Antimicrob Agents Chemother. 1985 May;27(5):851-7 - PubMed
    1. N Engl J Med. 1988 Sep 1;319(9):537-41 - PubMed
    1. Mol Microbiol. 1989 Jan;3(1):95-102 - PubMed
    1. Nucleic Acids Res. 1989 Jul 11;17(13):4937-46 - PubMed
    1. Nucleic Acids Res. 1989 Sep 25;17(18):7518 - PubMed

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