Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 May;40(5):1298-300.
doi: 10.1128/AAC.40.5.1298.

Trophozoite elimination in a rat model of Pneumocystis carinii pneumonia by clinically achievable plasma deferoxamine concentrations

S Merali  1 , K Chin, R W Grady, A B Clarkson Jr
Affiliations

Trophozoite elimination in a rat model of Pneumocystis carinii pneumonia by clinically achievable plasma deferoxamine concentrations

S Merali et al. Antimicrob Agents Chemother. 1996 May.

Abstract

In a rat model of Pneumocystis carinii pneumonia, a 3-week infusion of deferoxamine producing concentrations in plasma of > or = 1.5 micrograms m-1 eliminated the trophozoite life cycle stage. Since this concentration is well below that routinely achieved in patients treated for iron overload, deferoxamine has promise as a therapy for AIDS-associated P.carinii pneumonia.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Continuous axenic cultivation of Pneumocystis carinii.
    Merali S, Frevert U, Williams JH, Chin K, Bryan R, Clarkson AB Jr. Merali S, et al. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2402-7. doi: 10.1073/pnas.96.5.2402. Proc Natl Acad Sci U S A. 1999. PMID: 10051654 Free PMC article.

References

    1. Br J Haematol. 1979 Aug;42(4):547-55 - PubMed
    1. Antimicrob Agents Chemother. 1995 Jul;39(7):1442-4 - PubMed
    1. Semin Diagn Pathol. 1989 Aug;6(3):212-37 - PubMed
    1. Blood Rev. 1990 Mar;4(1):1-8 - PubMed
    1. J Clin Pathol. 1990 Apr;43(4):265-8 - PubMed

Publication types

LinkOut - more resources