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. 1996 May;43(5 Pt 1):511-3.
doi: 10.1007/BF03018114.

The precipitate formed by thiopentone and vecuronium

T Taniguchi  1 , K Yamamoto, T Kobayashi
Affiliations

The precipitate formed by thiopentone and vecuronium

T Taniguchi et al. Can J Anaesth. 1996 May.

Abstract

Purpose: To determine the composition and solubility of the precipitate formed by thiopentone and vecuronium in vitro.

Methods: The precipitate formed by mixing thiopentone 2.5% and vecuronium 0.1% at room temperature was analyzed by ultraviolet spectrophotometry and high performance liquid chromatography (HPLC). The solubility of the precipitate in human plasma was measured by HPLC.

Results: The UV absorption spectrum of the precipitate resembled that of thiopentone. HPLC analysis produced a single peak with the same retention time as thiopentone (4.6 min). In human plasma the solubility of the precipitate was not different from that of thiopentone acid. The solubility of thiopentone was greater than that of the precipitate.

Conclusion: The precipitate formed by thiopentone and vecuronium in vitro consisted of thiopentone acid, which was insoluble in human plasma.

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References

    1. Can J Anaesth. 1987 Jan;34(1):87-9 - PubMed
    1. J Chromatogr. 1978 May 1;145(3):492-5 - PubMed

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