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Case Reports
. 1977 Jun 15;77(3):397-405.
doi: 10.1016/0009-8981(77)90246-7.

(2-Ethoxyethoxy)acetic acid: an unusual compound found in the gas chromatographic analysis of urinary organic acids

J P Kamerling, M Duran, L Bruinvis, D Ketting, S K Wadman, C J de Groot, F A Hommes
Case Reports

(2-Ethoxyethoxy)acetic acid: an unusual compound found in the gas chromatographic analysis of urinary organic acids

J P Kamerling et al. Clin Chim Acta. .

Abstract

An unknown acidic compound was detected in a number of urine samples from patients with a suspected metabolic disorder and some patients treated with chemotherapy. The structure of this compound has been characterized as (2-ethoxyethoxy)acetic acid, using a gas chromatography/mass spectrometry/computer system. The authentic compound was synthesized and compared with the unknown. Urinary (2-ethoxyethoxy)acetic acid is assumed to be formed endogenously from an exogenous precursor, probably 2-(2-ethoxyethoxy)ethanol.

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