Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Jul;53(1):35-43.
doi: 10.1042/cs0530035.

Coeliac disease: the abolition of gliadin toxicity by enzymes from Aspergillus niger

J J Phelan, F M Stevens, B McNicholl, P F Fottrell, C F McCarthy

Coeliac disease: the abolition of gliadin toxicity by enzymes from Aspergillus niger

J J Phelan et al. Clin Sci Mol Med. 1977 Jul.

Abstract

1. Gliadin from which carbohydrate was removed by treatment with carbohydrase from Aspergillus niger was fed to three coeliac patients in remission. 2. Xylose absorption, mucosal morphology and brush-border enzymes were used to assess the toxicity of the carbohydrase-treated gliadin. 3. Gliadin treated with carbohydrases did not damage the intestinal mucosa of the coeliac patients. 4. The primary structure of the gliadin proteins was not altered by the enzyme treatment.

PubMed Disclaimer