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. 1996 Jun;143(2):713-21.
doi: 10.1093/genetics/143.2.713.

Destabilization of simple repetitive DNA sequences by transcription in yeast

M Wierdl  1 , C N Greene, A Datta, S Jinks-Robertson, T D Petes
Affiliations

Destabilization of simple repetitive DNA sequences by transcription in yeast

M Wierdl et al. Genetics. 1996 Jun.

Abstract

Simple repetitive DNA sequences in the eukaryotic genome frequently alter in length. In wild-type strains, we find that transcription through a repetitive poly GT tract destabilizes the tract four- to ninefold. In mismatch repair-deficient yeast strains, simple repeats are very unstable. High levels of transcription in such strains destabilize repetitive tracts an additional two- to threefold.

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