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. 1996 Apr;6(2):123-4.
doi: 10.1007/BF02291235.

Subcutaneous botulinum toxin type A inhibits regional sweating: an individual observation

W P Cheshire  1
Affiliations

Subcutaneous botulinum toxin type A inhibits regional sweating: an individual observation

W P Cheshire. Clin Auton Res. 1996 Apr.

Abstract

Botulinum toxin inhibits neuromuscular transmission by blocking the exocytosis of acetylcholine. It was tested for a similar effect on cholinergic postganglionic sympathetic neurones at the sudomotor junction. Subcutaneous injections of 0.1 and 1.0 units of type A botulinum toxin into the forearm of a healthy subject abolished local thermoregulatory sweating in cutaneous regions spanning 1.0 and 1.5 cm for nearly 1 year without producing weakness. Botulinum toxin, therefore appears to have potent anhidrotic activity.

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