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. 1977;18(4):231-7.
doi: 10.1159/000130765.

A simplified technique for in vivo analysis of sister-chromatid exchanges using 5-bromodeoxyuridine tablets

J W Allen, C F Shuler, R W Mendes, S A Latt

A simplified technique for in vivo analysis of sister-chromatid exchanges using 5-bromodeoxyuridine tablets

J W Allen et al. Cytogenet Cell Genet. 1977.

Abstract

A small tablet of 5-bromodeoxyuridine (BrdU), implanted subcutaneously in a mouse, provides sustained release of base analog sufficient to effect substitution of DNA throughout an entire replication period. As illustrated by studies of mouse bone-marrow and spleen cells in the presence or absence of cyclophosphamide, this depot method of BrdU administration greatly simplifies in vivo analysis of sister-chromatid-exchange formation.

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