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Review
. 1996 Apr;6(2):176-82.
doi: 10.1016/s0959-440x(96)80072-8.

Use of macromolecular assemblies as expression systems for peptides and synthetic vaccines

G P Lomonossoff  1 , J E Johnson
Affiliations
Review

Use of macromolecular assemblies as expression systems for peptides and synthetic vaccines

G P Lomonossoff et al. Curr Opin Struct Biol. 1996 Apr.

Abstract

The past decade has witnessed the development of numerous systems for the presentation of antigens on the surface of self-assembling macromolecules. Although the sites for insertion were initially chosen empirically, the determination of the three-dimensional structures of a number of carrier macromolecules has enabled structure-based insertional mutagenesis to be used increasingly. Furthermore, it is now feasible to determine the structure of an inserted sequence as presented in a heterologous environment, making it possible to correlate the detailed structure of a peptide with its immunological properties.

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