Clinical relevance of hepatitis C virus quasispecies
- PMID: 8732171
- DOI: 10.1111/j.1365-2893.1995.tb00040.x
Clinical relevance of hepatitis C virus quasispecies
Abstract
It has been shown that hepatitis C virus (HCV) populations in infected individuals are composed of quasispecies with diverse mutations. The analysis of these variants may reveal mechanisms of the persistence of HCV infection, carcinogenesis and resistance to antiviral therapy. Recently, genetic features of interferon-resistant HCV have been elucidated through the analysis of interferon-resistant quasispecies, making it possible to predict interferon efficacy by detecting interferon-resistant strains.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
