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. 1996 Apr;134(4):657-61.
doi: 10.1111/j.1365-2133.1996.tb06965.x.

Soluble intercellular adhesion molecule-1 and soluble E-selectin levels in patients with atopic dermatitis

S Hirai  1 , T Kageshita, T Kimura, M Tsujisaki, K Okajima, K Imai, T Ono
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Soluble intercellular adhesion molecule-1 and soluble E-selectin levels in patients with atopic dermatitis

S Hirai et al. Br J Dermatol. 1996 Apr.

Abstract

The serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) were determined by double determinant immunoassay (DDIA), in 37 patients with atopic dermatitis (AD) and 31 age- and sex-matched healthy control subjects. Both sICAM-1 and sE-selectin levels were significantly higher in patients with AD than in healthy controls (P < 0.01), and were correlated with disease severity. A longitudinal study of patients with AD revealed that the levels of sICAM-1 decreased in those in whom symptoms improved. The sICAM-1 levels were significantly correlated with those of sE-selectin. Our studies suggest that such high levels of serum sICAM-1 and sE-selectin may affect the immune response in patients with AD. The levels of sICAM-1 and sE-selectin may be a useful immunological parameter for monitoring disease activity in AD.

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