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. 1979 Mar 15;35(3):411-2.
doi: 10.1007/BF01964383.

Association between pregnancy-associated alpha2-glycoprotein (alpha2-PAG) and mixed leucocyte reaction determinants on the leucocyte surface

C H Horne, A W Thomson, C B Hunter, V van Heyningen, D L Deane, C M Steel

Association between pregnancy-associated alpha2-glycoprotein (alpha2-PAG) and mixed leucocyte reaction determinants on the leucocyte surface

C H Horne et al. Experientia. .

Abstract

alpha2-PAG is present on the surface on mononuclear blood leucocytes and can be demonstrated predominantly on B-lymphocytes and monocytes. Pretreatment of cells with antibody to alpha2-PAG leads to a marked reduction in Fc-rosette formation. Competitive blocking experiments with specific antisera reveal a particularly close association between alpha2-PAG and MLR (mixed leucocyte reaction) determinants on the cell surface. These findings suggest one mechanism whereby alpha2-PAG may modify cell-mediated immune responses.

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