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. 1996 May;41(5):421-4.
doi: 10.1046/j.1365-2125.1996.33311.x.

Inhibition of caffeine metabolism by 5-methoxypsoralen in patients with psoriasis

E K Bendriss  1 , Y Bechtel, A Bendriss, P H Humbert, G Paintaud, J Magnette, P Agache, P R Bechtel
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Inhibition of caffeine metabolism by 5-methoxypsoralen in patients with psoriasis

E K Bendriss et al. Br J Clin Pharmacol. 1996 May.

Abstract

Eight patients with psoriasis were given 200 mg caffeine orally with or without 1.2 mg kg-1 of 5-methoxypsoralen. Blood and urine samples were collected over a 2-day period. During 5-methoxypsoralen coadministration, the apparent volume of distribution of caffeine remained unchanged, but oral clearance (CLp.o.) decreased from 9.5 +/- 3.8 (mean +/- s.d.) to 3.2 +/- 0.51 h-1 (P < 0.01). The area under the plasma concentration-time curve (AUC) increased from 24 +/- 9 to 73 +/- 29 mg 1(-1) h (P < 0.001). This decrease in CLp.o. with increased AUC was consistent with a CYP1A2-dependent inhibition of caffeine N-demethylation which was further supported by significant decreases in the (AFMU+1U+1X)/17U and (AFMU+1U+1X)/17X urinary metabolic ratios.

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