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Case Reports
. 1996 Mar-Apr;14(2):125-30.

CD4 cytopenia and occasional expansion of CD4+CD8+lymphocytes in Sjögren's syndrome

G F Ferraccioli  1 , E Tonutti, L Casatta, I Pegoraro, S De Vita, P Sala, T Ravaioli, E Bartoli
Affiliations
  • PMID: 8737717
Case Reports

CD4 cytopenia and occasional expansion of CD4+CD8+lymphocytes in Sjögren's syndrome

G F Ferraccioli et al. Clin Exp Rheumatol. 1996 Mar-Apr.

Abstract

Objectives: To define whether Sjögren's syndrome (SS) patients have lymphocytopenia compared to healthy controls, and to assess which lymphocyte subset might be involved. The presence of any concurrent infection was recorded.

Methods: A cohort of ten consecutive patients with SS was studied, and the results were compared with ten sex- and age-matched controls (C).

Results: In SS, a significant cytopenia of CD4+ (679 +/- 339 vs 1110 +/- 222 cells/mm3, p < 0.005) and an even more impressive decrease in the CD4+CD45 RA+ (242 +/- 154 vs 491 +/- 190 cells/mm3, p < 0.005) subset was observed. An absolute CD4 lymphocytopenia (CD4+ < 300 cells/mm3) was seen in two patients. In one patient an unusual finding was the expansion of a double positive population of CD4+CD8+ lymphocytes. No striking relationship with any particular infection was shown. A retrospective review of the absolute CD4+ cytopenia in 54 consecutive SS cases revealed a prevalence of 5.5%.

Conclusion: Some SS patients have T lymphocytopenia which mainly affects the CD4+CD45 RA+ subset. Occasional cases with absolute CD4 lymphocytopenia may also be observed. These patients show some evidence of mild recurrent or chronic, but never severe, opportunistic infections.

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