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Review
. 1996 Apr;35(4):285-9.
doi: 10.2169/internalmedicine.35.285.

Multiple endocrine neoplasia type 1 associated with spinal ependymoma

H Kato  1 , I Uchimura, M Morohoshi, K Fujisawa, Y Kobayashi, F Numano, N Goseki, M Endo, A Tamura, C Nagashima
Affiliations
Free article
Review

Multiple endocrine neoplasia type 1 associated with spinal ependymoma

H Kato et al. Intern Med. 1996 Apr.
Free article

Abstract

A 51-year-old man was hospitalized with a gait disturbance and hypoesthesia below the level of his chest. These symptoms were due to a spinal tumor which was surgically resected and identified as an ependymoma. Additionally, the patient had hypercalcemia and a family history of insulinoma. An endocrine evaluation revealed parathyroid hyperplasia and a pancreatic islet cell tumor. Magnetic resonance imaging disclosed a pituitary microadenoma. He was diagnosed with spinal ependymoma and multiple endocrine neoplasia type 1 (MEN 1). A review of the literature revealed that chromosome 11q13 abnormalities have been reported in both ependymoma and MEN 1. We discuss the pathogenesis of these diseases.

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