Secretion of parathyroid hormone by abnormal human parathyroid glands in vitro
- PMID: 874057
- DOI: 10.1210/jcem-45-1-105
Secretion of parathyroid hormone by abnormal human parathyroid glands in vitro
Abstract
The secretory response of abnormal parathyroid glands obtained surgically from eleven patients with primary and secondary hyperparathyroidsm was tested in vitro. Short term flask studies were used to measure release of parathyroid hormone (PTH) at high (3.0 mM) and low (0.5 mM) calcium. Of eight adenomas, all but one showed increased release of hormone when exposed to low calcium ("responsive to calcium"), the degree of stimulation at three hours ranging from 15 to 209%. By comparison, two normal human glands were stimulated an average of 180%. Glands from three patients with secondary hyperplasia were also responsive to calcium. Thus, parathyroid glands from patients with primary and secondary hyperparathyroidism were characterized by a spectrum of responsiveness to calcium, and absolute "autonomy" was unusual. Even at high calcium concentrations, hormone release persisted at a low but definite level ("basal secretion"). The total number of functioning parathyroid cells is therefore a principal determinant in the oversecretion of PTH in hyperparathyroidism.
Similar articles
-
Responsiveness of neoplastic and hyperplastic parathyroid tissues to calcium in vitro.J Clin Invest. 1978 Aug;62(2):436-50. doi: 10.1172/JCI109145. J Clin Invest. 1978. PMID: 670402 Free PMC article.
-
Abnormal regulation of parathyroid hormone release by calcium in secondary hyperparathyroidism due to chronic renal failure.J Clin Endocrinol Metab. 1982 Jan;54(1):172-9. doi: 10.1210/jcem-54-1-172. J Clin Endocrinol Metab. 1982. PMID: 7054214
-
Secretory and ultrastructural responses of hyperfunctioning human parathyroid tissues to varying calcium concentration and vinblastine.Lab Invest. 1977 Feb;36(2):198-205. Lab Invest. 1977. PMID: 839734
-
In vivo studies of parathyroid gland function in secondary hyperparathyroidism.Adv Nephrol Necker Hosp. 1996;25:289-302. Adv Nephrol Necker Hosp. 1996. PMID: 8717632 Review.
-
MicroRNAs in parathyroid physiopathology.Mol Cell Endocrinol. 2017 Nov 15;456:9-15. doi: 10.1016/j.mce.2016.10.035. Epub 2016 Nov 2. Mol Cell Endocrinol. 2017. PMID: 27816765 Review.
Cited by
-
Primary hyperparathyroidism caused by parathyroid-targeted overexpression of cyclin D1 in transgenic mice.J Clin Invest. 2001 May;107(9):1093-102. doi: 10.1172/JCI10523. J Clin Invest. 2001. PMID: 11342573 Free PMC article.
-
Calcium-sensing receptor in cancer: good cop or bad cop?Endocrine. 2009 Jun;35(3):271-84. doi: 10.1007/s12020-008-9131-5. Epub 2008 Nov 15. Endocrine. 2009. PMID: 19011996 Review.
-
Direct release of parathyroid hormone fragments from functioning bovine parathyroid glands in vitro.J Clin Invest. 1978 Dec;62(6):1247-54. doi: 10.1172/JCI109245. J Clin Invest. 1978. PMID: 748378 Free PMC article.
-
The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future.Front Physiol. 2016 Dec 15;7:563. doi: 10.3389/fphys.2016.00563. eCollection 2016. Front Physiol. 2016. PMID: 28018229 Free PMC article. Review.
-
Responsiveness of neoplastic and hyperplastic parathyroid tissues to calcium in vitro.J Clin Invest. 1978 Aug;62(2):436-50. doi: 10.1172/JCI109145. J Clin Invest. 1978. PMID: 670402 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources