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Clinical Trial
. 1996 Jun;34(6):639-45.

[Use of the the ED046 kit to analyze serum KL-6 in patients with pneumonitis]

[Article in Japanese]
S Kitamura  1 , K Hiwada, J Kobayashi, N Kohno, T Kawai, A Satou, R Kasukawa, Y Kawakami, M Andou, G Nakada, H Inoue, K Itou, T Matsushima, T Ogura, M Arakawa, M Yamakido
Affiliations
  • PMID: 8741528
Clinical Trial

[Use of the the ED046 kit to analyze serum KL-6 in patients with pneumonitis]

[Article in Japanese]
S Kitamura et al. Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Jun.

Abstract

KL-6 is a mucinous glycoprotein expressed on Type 2 pneumonocytes, and serum levels of KL-6 are reported to be abnormally high in patients with interstitial pneumonia. A new assay kit for serum KL-6 (ED046) was used in the evaluation of patients with pneumonitis. To clarify whether KL-6 is a useful marker of pneumonitis activity, 649 subjects were studied, including 185 healthy controls, 187 patients with 3 types of interstitial lung diseases, and 277 patients with 4 types of non-interstitial lung diseases. The serum KL-6 level was significantly higher in the patients with pneumonitis (1285 +/- 1196 U/ml) than in the patients without pneumonitis (307 +/- 232 U/ml). The KL-6 level was also significantly higher in patients with clinically active pneumonitis (1708 +/- 1338 U/ml) than in those with inactive pneumonitis (820 +/- 796 U/ml) (p < 0.0001). Serum KL-6 levels correlated significantly with serum c-reactive protein, lactic dehydrogenase, and PaO2 values. These results suggest that the ED046 assay is useful for measuring KL-6 as a marker of pneumonitis activity.

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