Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Jul;90(1):118-24.

The role of RNA metabolism in polymorphonuclear leukocyte phagocytosis

D O Kasprisin, M B Harris
  • PMID: 874363

The role of RNA metabolism in polymorphonuclear leukocyte phagocytosis

D O Kasprisin et al. J Lab Clin Med. 1977 Jul.

Abstract

The role of RNA metabolism in human PMN phagocytosis was examined. By the inhibition of RNA synthesis with actinomycin D, intracellular killing of a strain of actinomycin D-resistant S. epidermidis was unaffected by 1 hr but significantly decreased by 2 and 3 hr. After 1 hr, phagocytosis began to decrease, and iodination of proteins also decreased in the presence of actinomycin D. Hexosemonophosphate shunt activity remained similar for both actinomycin D treated PMN's and control cells at 30 min and 2 hr. Protein synthesis was inhibited by incubating PMN's with puromycin. The ability of the PMN's to kill puromycin-resistant S. epidermidis was significantly decreased at 2 and 3 hr.

PubMed Disclaimer