Interferon-induced enhancement of IgE-mediated histamine release from human basophils requires RNA synthesis
- PMID: 87438
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Interferon-induced enhancement of IgE-mediated histamine release from human basophils requires RNA synthesis
J Immunol.
1979 Apr.
Abstract
Incubation of human leukocytes with certain viruses results in the enhancement of IgE-mediated release of histamine. This enhancement is produced by interferon. The present experiments show that an induction period of 6 to 9 hr and new RNA synthesis are required for interferon to enhance histamine release. This points to the possibility that interferon may exert its antiviral and histamine-release enhancing activities by acting through a common pathway.
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