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Review
. 1996 Apr;7(2):69-76.
doi: 10.1097/00041433-199604000-00004.

Paraoxonase: biochemistry, genetics and relationship to plasma lipoproteins

M I Mackness  1 , B Mackness, P N Durrington, P W Connelly, R A Hegele
Affiliations
Review

Paraoxonase: biochemistry, genetics and relationship to plasma lipoproteins

M I Mackness et al. Curr Opin Lipidol. 1996 Apr.

Abstract

Human serum paraoxonase is located on an HDL. It has the capacity to retard the accumulation of lipid peroxides in LDL under oxidizing conditions in vitro. Paraoxonase has a genetic polymorphism that results in a single amino acid substitution. Evidence indicates that both the serum concentration of paraoxonase and an individual's genotype are related to plasma lipid and lipoprotein concentrations, and possibly also to coronary heart disease, implicating paraoxonase in the development of atherosclerosis.

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