Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Apr;40(4):404-14.
doi: 10.1136/jnnp.40.4.404.

Epileptiform syndrome in rats produced by injecting tetanus toxin into the hippocampus

J Mellanby, G George, A Robinson, P Thompson

Epileptiform syndrome in rats produced by injecting tetanus toxin into the hippocampus

J Mellanby et al. J Neurol Neurosurg Psychiatry. 1977 Apr.

Abstract

An epileptiform syndrome in rats produced by injecting small doses (a few (mouse)LD50) of tetanus toxin into the hippocampus is described. The animals had intermittent seizures, with at least a superficial resemblance to human epilepsy, for some weeks but they eventually recovered. They were hyperkinetic for several weeks after the injection of toxin, and showed intermittent aggressive behaviour. Control animals which received similar injections of tetanus toxin first neutralised with antitoxin did not have seizures, and their behaviour appeared normal. EEG recordings showed characteristic seizure activity. Histological examination of the site of injection showed very little morphological damage.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Physiol. 1948 Jan 1;107(1):45-53 - PubMed
    1. Physiol Rev. 1964 Oct;44:561-608 - PubMed
    1. Science. 1962 Aug 3;137(3527):342-3 - PubMed
    1. Science. 1962 Aug 31;137(3531):674-6 - PubMed
    1. AMA Arch Neurol Psychiatry. 1957 Sep;78(3):259-63 - PubMed

LinkOut - more resources