[Alkaline phosphatase levels in gingival crevicular fluid of periodontitis before and after periodontal treatment]

Abstract

Gingival crevicular fluid (GCF) samples were collected from 204 teeth from 35 subjects, including 8 rapidly progressive periodontitis (RPP), 14 chronic adult periodontitis (CAP), 7 marginal gingivitis (MG) and 6 healthy subjects (H). The results of alkaline phosphatase (ALP) examination indicated that the ALP levels from CAP and RPP patients were significantly higher than those from H subjects and MG patients. The ALP levels were closely related to the amount of GCF flow and various clinical periodontal parameters, especially to probing depth and attachment loss. The ALP levels and the various clinical parameters decreased significantly after periodontal therapy. The present study suggests that the measurement of GCF--ALP could be an useful adjuctive criterion for detection of periodontal inflammatory status and extent of tissue destruction.