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Review
. 1995 Dec:89 Suppl 1:55-73.
doi: 10.1080/00034983.1995.11813015.

Experimental models for leishmaniasis and for testing anti-leishmanial vaccines

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Review

Experimental models for leishmaniasis and for testing anti-leishmanial vaccines

M Hommel et al. Ann Trop Med Parasitol. 1995 Dec.

Abstract

In public health terms, leishmaniases are diseases of humans and dogs, whereas, in epidemiological terms, Leishmania spp. are considered to represent infections of a wide variety of animals, which represent the natural reservoirs of the various parasite species involved. Humans and dogs (which may be considered secondary or 'accidental' hosts in the leishmanial life-cycle) often exhibit severe clinical signs and symptoms when infected, whereas reservoir hosts generally show a few, minor or no signs. This situation makes the definition of a suitable laboratory model a difficult one, since the various experimental hosts may behave either like a reservoir or an accidental host. This review discusses the concept of animal models for leishmaniases and provides a critical evaluation of the most common experimental models and their respective advantages and disadvantages. In this state-of-the-art review, particular emphasis is given to the value of using mouse, hamster, cotton-rat, dog and primate models, especially in the context of testing potential anti-leishmanial vaccines.

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