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Case Reports
. 1995 Dec;12(4):311-3.
doi: 10.1111/j.1525-1470.1995.tb00190.x.

Acute graft-versus-host disease with unusual cutaneous intracellular vacuolation in an infant with severe combined immunodeficiency

A Farrell  1 , L Scerri, A Stevens, L G Millard
Affiliations
Case Reports

Acute graft-versus-host disease with unusual cutaneous intracellular vacuolation in an infant with severe combined immunodeficiency

A Farrell et al. Pediatr Dermatol. 1995 Dec.

Abstract

We report an infant with severe combined immunodeficiency (SCID) who had cutaneous manifestations of acute graft-versus-host disease (GVHD) due to maternofetal lymphocyte engraftment. Histologic and ultrastructural examinations of the skin revealed intracellular vacuoles resembling lipid droplets in the epidermis and dermis, which is not a recognized feature of acute GVHD or SCID.

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