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. 1977 Jun;267(3):659-66.
doi: 10.1113/jphysiol.1977.sp011831.

Endogenous pyrogen-like substance produced by reptiles

H A Bernheim, M J Kluger

Endogenous pyrogen-like substance produced by reptiles

H A Bernheim et al. J Physiol. 1977 Jun.

Abstract

1. Injection of lizards (Dipsosaurus dorsalis) with rabbit endogenous pyrogen led to a fever. Injections with denatured endogenous pyrogen did not affect body temperature. 2. Injection of lizards with lizard endogenous pyrogen led to a fever of short duration, while injection of denatured lizard endogenous pyrogen produced no change in body temperature. 3. These data support the hypothesis that the febrile mechanism observed in the higher vertebrates has its origins in some primitive vertebrate.

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