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Review
. 1995 Dec;5(6):728-34.
doi: 10.1016/0959-440x(95)80004-2.

Protein phosphatases

D Barford  1
Affiliations
Review

Protein phosphatases

D Barford. Curr Opin Struct Biol. 1995 Dec.

Abstract

Protein phosphatases are signal transducing enzymes that dephosphorylate cellular phosphoproteins. The recently determined crystal structures of protein tyrosine and serine/threonine phosphatases reveal that these proteins adopt distinct structures and catalyze dephosphorylation reactions by means of different enzymatic mechanisms. Insights into the basis for substrate specificity and enzyme regulation can also be gained from these crystal structures.

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