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. 1977 Jul;20(7):939-43.
doi: 10.1021/jm00217a015.

Anticoccidial 1-substituted 4(1H)-pyridinone hydrazones

A W Douglas, M H Fisher, J J Fishinger, P Gund, E E Harris, G Olson, A A Patchett, W V Ruyle

Anticoccidial 1-substituted 4(1H)-pyridinone hydrazones

A W Douglas et al. J Med Chem. 1977 Jul.

Abstract

4-Chlorobenzaldehyde 1-(4-chlorophenyl)-4(1H)-pyridinylidene hydrazone fluorusulfonate (4) was found to have excellent anticoccidial activity in chickens. The synthesis and biological evaluation of related analogues are presented. Presumably 4 shares a common mechanism of action with robenidine (25) since it was not active on a robenidine tolerant strain of E. tenella. Structural comparisons of the two molecules are presented.

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