Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1995;70(1):64-7.
doi: 10.1007/s002040050251.

In vitro biotransformation of 2-methylpropene (isobutene) in rat lung tissue in comparison with liver tissue

M Cornet  1 , A Callaerts, A Vercruysse, V Rogiers
Affiliations
Comparative Study

In vitro biotransformation of 2-methylpropene (isobutene) in rat lung tissue in comparison with liver tissue

M Cornet et al. Arch Toxicol. 1995.

Abstract

The epoxidation of the gaseous alkene 2-methylpropene or isobutene was studied in vitro in rat lung tissue in comparison with rat liver. Pulmonary tissue appears to be less exposed to the toxic epoxide metabolite than is the case for hepatic tissue. The results are correlated with the low capacity of the mixed function oxidase system, expressed by means of the cytochrome P-450 content and the 7-ethoxycoumarin O-deethylase activity, to form reactive intermediates. The activities of the principal epoxide detoxifying enzymes glutathione S-transferase and epoxide hydrolase represent only 5-10% of the values measured in rat liver.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Toxicology. 1992;73(2):147-60 - PubMed
    1. Mutat Res. 1992 Jun;271(3):213-21 - PubMed
    1. Crit Rev Toxicol. 1985;14(3):259-307 - PubMed
    1. Pharmacol Ther. 1990;45(3):299-307 - PubMed
    1. Pharmacol Ther. 1989;41(1-2):243-56 - PubMed

Publication types

LinkOut - more resources