Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996;288(1):11-3.
doi: 10.1007/BF02505036.

Defective calcium transport in vitiliginous melanocytes

K U Schallreuter-Wood  1 , M R Pittelkow, N N Swanson
Affiliations

Defective calcium transport in vitiliginous melanocytes

K U Schallreuter-Wood et al. Arch Dermatol Res. 1996.

Abstract

Melanocytes were successfully established from involved and uninvolved skin of a patient with acute acrofacial vitiligo. Cells from involved epidermis showed a fivefold decrease in the rate of radiolabelled 45Ca uptake compared with uninvolved and control cells. These results are similar to previous findings in keratinocytes from involved skin in patients with vitiligo. Since 6-biopterin is cytotoxic to melanocytes and calcium controls the redox status of the 6-biopterin/(6R)5, 6, 7, 8-tetrahydrobiopterin equilibrium via the thioredoxin reductase/thioredoxin system, these results underline the importance of this electron transfer system for both melanocyte function and survival.

PubMed Disclaimer

References

    1. Arch Dermatol Res. 1988;280(3):137-9 - PubMed
    1. Biochim Biophys Acta. 1994 May 25;1226(2):181-92 - PubMed
    1. Arch Dermatol Res. 1993;285(4):216-20 - PubMed
    1. Dermatology. 1995;190(2):109-15 - PubMed
    1. Arch Dermatol Res. 1996;288(1):14-8 - PubMed

LinkOut - more resources