Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Sep;64(9):3934-6.
doi: 10.1128/iai.64.9.3934-3936.1996.

Urease activity does not contribute dramatically to persistence of Mycobacterium bovis bacillus Calmette-Guérin

J M Reyrat  1 , G Lopez-Ramirez, C Ofredo, B Gicquel, N Winter
Affiliations

Urease activity does not contribute dramatically to persistence of Mycobacterium bovis bacillus Calmette-Guérin

J M Reyrat et al. Infect Immun. 1996 Sep.

Abstract

Multiplication of BCGure-, an isogenic urease-negative mutant of Mycobacterium bovis BCG constructed by allelic exchange (J. M. Reyrat, F. X. Berthet, and B. Gicquel, Proc. Natl. Acad. Sci. USA 92:8768-8772, 1995), was examined in human macrophages and mice. Although ureolytic activity was not essential to BCGure-growth, a slight decrease in the multiplication and persistence of the mutated strain compared with wild-type BCG was observed in lungs of infected mice.

PubMed Disclaimer

References

    1. Science. 1994 Feb 4;263(5147):678-81 - PubMed
    1. Infect Immun. 1993 Jul;61(7):2763-73 - PubMed
    1. Infect Immun. 1995 Mar;63(3):1004-12 - PubMed
    1. Infect Immun. 1995 Sep;63(9):3428-37 - PubMed
    1. Nature. 1980 Jul 3;286(5768):79-80 - PubMed

Publication types

LinkOut - more resources