Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1996 May;26(3):279-92.
doi: 10.1007/BF02359384.

Application of antisense DNA method for the study of molecular bases of brain function and behavior

S Ogawa  1 , D W Pfaff
Affiliations
Review

Application of antisense DNA method for the study of molecular bases of brain function and behavior

S Ogawa et al. Behav Genet. 1996 May.

Abstract

The antisense DNA method has been used successfully not only in vitro but also with in vivo systems to block effectively the expression of specific genes. An increasing number of studies have shown that antisense DNA administered directly into the brain can modify various kinds of behaviors. These findings strongly suggest that the antisense DNA method can be widely used as a powerful tool for the study of the molecular bases of behavior. In addition to traditional methods of behavioral genetics, the antisense DNA method may provide a new approach for the study of the effects of gene in behavioral function. In this article, we review recent studies reporting in vivo effects of antisense DNA on brain function and behavior.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Neurosci. 1994 Mar;14(3 Pt 2):1766-74 - PubMed
    1. J Biol Chem. 1993 Aug 15;268(23 ):17427-30 - PubMed
    1. Biochem Biophys Res Commun. 1993 Dec 15;197(2):818-25 - PubMed
    1. Am J Physiol. 1993 Jul;265(1 Pt 1):L1-12 - PubMed
    1. Brain Res. 1986 Oct 1;384(1):121-31 - PubMed

LinkOut - more resources