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. 1996 Aug 15;382(6592):595-601.
doi: 10.1038/382595a0.

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

T Bouwmeester  1 , S Kim, Y Sasai, B Lu, E M De Robertis
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Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

T Bouwmeester et al. Nature. .

Abstract

An abundant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.

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