doi: 10.1038/382595a0.
Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer
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- PMID: 8757128
- DOI: 10.1038/382595a0
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Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer
Nature.
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Abstract
An abundant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.
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