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. 1996 May-Jun;90(3):270-3.
doi: 10.1016/s0035-9203(96)90243-6.

Association between serum levels of reactive nitrogen intermediates and coma in children with cerebral malaria in Papua New Guinea

F M Al Yaman  1 , D Mokela, B Genton, K A Rockett, M P Alpers, I A Clark
Affiliations

Association between serum levels of reactive nitrogen intermediates and coma in children with cerebral malaria in Papua New Guinea

F M Al Yaman et al. Trans R Soc Trop Med Hyg. 1996 May-Jun.

Abstract

Serum levels of reactive nitrogen intermediates (RNI; nitrate plus nitrite) were measured in 92 patients with cerebral malaria in the Madang Province of Papua New Guinea. RNI levels were compared to disease severity and clinical outcome, and correlated with both the depth of coma on admission and its duration. Median levels were higher among children with deeper coma than among those with lighter coma (35.6 microM vs. 16.7 microM; P = 0.008) and also among children with longer duration of coma (72 h; 59.3 microM vs. 19.3 microM; P = 0.004). RNI levels also correlated with clinical outcome, fatal cases having significantly higher RNI levels than survivors (41.2 microM vs. 18.5 microM; P = 0.014). Thus, high RNI levels are associated with indices of disease severity and may predict outcome in children with cerebral malaria. These data are consistent with the hypothesis that nitric oxide is involved in the pathogenesis of coma in human cerebral malaria.

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Comment in

  • Reactive nitrogen intermediates and cerebral malaria.
    Prada J, Kremsner PG. Prada J, et al. Trans R Soc Trop Med Hyg. 1997 Jan-Feb;91(1):92-3. doi: 10.1016/s0035-9203(97)90411-9. Trans R Soc Trop Med Hyg. 1997. PMID: 9093641 No abstract available.
  • Nitrate levels in malaria.
    Anstey NM, Granger DL, Weinberg JB. Anstey NM, et al. Trans R Soc Trop Med Hyg. 1997 Mar-Apr;91(2):238-40. doi: 10.1016/s0035-9203(97)90237-6. Trans R Soc Trop Med Hyg. 1997. PMID: 9196781 No abstract available.

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