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. 1996 Aug;94(2):318-23.
doi: 10.1046/j.1365-2141.1996.d01-1811.x.

A plasmocyte selective monoclonal antibody (B-B4) recognizes syndecan-1

J Wijdenes  1 , W C Vooijs, C Clément, J Post, F Morard, N Vita, P Laurent, R X Sun, B Klein, J M Dore
Affiliations

A plasmocyte selective monoclonal antibody (B-B4) recognizes syndecan-1

J Wijdenes et al. Br J Haematol. 1996 Aug.

Abstract

We developed a new monoclonal antibody. B-B4, which specifically identifies human plasma cells. It strongly reacts with all multiple myeloma cell lines and with malignant plasma cells of all tumour samples of the multiple myeloma patients tested. B-B4 does not react with any peripheral blood, bone marrow or tonsil cells. Cloning of the B-B4 antigen reveals that the monoclonal antibody recognizes syndecan-1. It appears that the monoclonal antibody B-B4 is a suitable marker for human plasmocyte identification among haemopoietic cells and a useful probe for the diagnosis of haematological malignancies. Furthermore, this monoclonal antibody can be used for depletions prior to CD34 grafting.

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