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Review
. 1996 Jun 29;25(23):1066-8.

[Nephrotic syndrome complicating treatment with interferon alpha]

[Article in French]
M Dhib  1 , E Bakhache, E Postec, B Vanrenterghem, F Le Roy, R Azar, A François, A Boldron, R Amaria, G Ozenne, A Hermelin
Affiliations
  • PMID: 8760627
Review

[Nephrotic syndrome complicating treatment with interferon alpha]

[Article in French]
M Dhib et al. Presse Med. .

Abstract

We report two cases of nephrotic syndrome with minimal glomerular change complicating alpha-interferon therapy.

Case reports: The first patient was a 60-year-old man with Waldenström's disease who was given 1 million units of alpha-interferon three times a week for 22 months. Acute renal failure developed when a second protocol was started. Renal biopsy revealed intraglomerular deposits and no cellular proliferation. Total remission could not be achieved with corticosteroids. The second case was a 46-year-old man given high dose alpha-interferon (15 million units 3 times a week) for lymph node metastasis of a malignant melanoma. A nephrotic syndrome without renal failure developed during the third month of treatment. Minimal glomerular involvement was seen. Symptomatic treatment led to resolution of the nephrotic syndrome.

Discussion: Nine other cases of nephrotic syndrome complicating alpha-interferon therapy have been reported in the literature.

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