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. 1996 Aug;117(1):159-64.
doi: 10.1017/s0950268800001266.

Seroprevalence of astrovirus types 1 and 6 in London, determined using recombinant virus antigen

S Kriston  1 , M M Willcocks, M J Carter, W D Cubitt
Affiliations

Seroprevalence of astrovirus types 1 and 6 in London, determined using recombinant virus antigen

S Kriston et al. Epidemiol Infect. 1996 Aug.

Abstract

We have developed a microimmunofluorescence test (IF) which uses cells infected with a recombinant baculovirus which expresses the capsid proteins of astrovirus types 1 or 6. The IF test was sensitive and specific and the results for human astrovirus type 1 (HAst-1) were comparable to those obtained by immune electronmicroscopy and radioimmunoassay. Application of the test to a panel of 273 sera collected from patients and staff at two childrens hospitals in London showed that over 50% of the population were infected by HAst-1 between the age of 5 and 12 months rising to 90% by 5 years, whereas human astrovirus type 6 (HAst6) was relatively uncommon (10-30%) in all age groups.

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