Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Aug;101(4):298-303.
doi: 10.1016/0924-980x(96)94645-7.

Postexcitatory inhibition after transcranial magnetic single and double brain stimulation in Huntington's disease

M Tegenthoff  1 , M Vorgerd, F Juskowiak, V Roos, J P Malin
Affiliations

Postexcitatory inhibition after transcranial magnetic single and double brain stimulation in Huntington's disease

M Tegenthoff et al. Electroencephalogr Clin Neurophysiol. 1996 Aug.

Abstract

Postexcitatory inhibition (pI) was studied in 13 patients with different clinical forms of Huntington's disease (HD), using a transcranial magnetic single and double stimulation paradigm. We found pathological results of pI in 77% of the HD patients. A significant prolongation of pI could be demonstrated in the group of patients suffering from a classical form of HD. In contrast to these patients, those patients suffering from primary rigid HD variants exhibited a shortening of pI. These results suggest an altered excitability of the motor cortex in HD according to dysfunctions within the motor cortex-basal ganglia loop. Transcranial double stimulation was a more sensitive measure in detecting changes of cortical excitation levels than single stimulation. The interpretation of pI changes in HD has to take the clinical subtype of HD into account.

PubMed Disclaimer