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. 1995;40(6):607-10.
doi: 10.1007/BF02818516.

Exogenous shikimic acid stimulates rapamycin biosynthesis in Streptomyces hygroscopicus

A Fang  1 , A L Demain
Affiliations

Exogenous shikimic acid stimulates rapamycin biosynthesis in Streptomyces hygroscopicus

A Fang et al. Folia Microbiol (Praha). 1995.

Abstract

A chemically defined medium was developed which satisfies the nutritional needs of the Streptomyces hygroscopicus strain producing the immunosuppressant rapamycin. More than a doubling of rapamycin biosynthesis was observed on addition of 57 mmol/L of exogenous shikimate. The previously observed inhibition of the synthesis by phenylalanine was not reversed by shikimate.

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References

    1. J Antibiot (Tokyo). 1987 Sep;40(9):1249-55 - PubMed
    1. Med Res Rev. 1994 Jan;14(1):1-22 - PubMed
    1. J Ind Microbiol. 1995 May;14(5):424-7 - PubMed
    1. J Antibiot (Tokyo). 1988 Nov;41(11):1592-601 - PubMed
    1. J Nat Prod. 1991 Jan-Feb;54(1):167-77 - PubMed

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